Product Name: 5-Hydroxytryptophan
CAS: 56-69-9; 4350-09-8
Grade: Pharmaceutical Grade
Appearance: White Powder
5-Hydroxytryptophan (5-HTP) is a supplement that some people use in an effort to support their mental health and immune system. It is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitters serotonin and melatonin from tryptophan.
5-HTP is sometimes taken by people coming down from MDMA to relieve post-MDMA dysphoria. As 5-HTP is a necessary precursor for the brain to produce more serotonin, and MDMA use depletes a person's natural serotonin levels, it is believed that taking 5-HTP after consuming MDMA will speed up serotonin production.
5-HTP has been used for a variety of conditions including anxiety, various sleep disorders, hyperactivity disorders, cerebellar ataxia, depression, primary fibromyalgia syndrome, and migraines.
However, medicinal use of 5-HTP has not been approved by the Food and Drug Administration (FDA), and much of the information available regarding 5-HTP's use is anecdotal and not supported by research. It's also important to note that not all of the research available on 5-HTP includes studies done in humans, but in animals, and more research is needed to determine if 5-HTP is a safe or effective supplement.
5-HTP is a naturally-occurring chemical in the body and is a building block to serotonin, which is a neurotransmitter that helps moderate the transmission of signals between nerve cells.
1. Weight Loss. Some studies show that 5-HTP appears to help support weight loss by causing a decrease in appetite.
2. Anxiety. Given the fact that 5-HTP is a building block or precursor to the mood-enhancing chemical serotonin, scientists have explored the potential benefit of 5-HTP in lowering anxiety.
3. Depression. Because of serotonin's known benefit in treating depression, 5-HTP is thought to possibly play a beneficial role in alleviating the symptoms of depression.
4. Sleep Disorders. Some research shows that, when taken along with another supplement called gamma aminobutyric acid (GABA), the combination of the two together might help people not only fall asleep faster but sleep more restfully.
A typical dose of 5-HTP is in the range of 300-500 mg, taken either once daily or in divided doses. Lower doses may also be effective, although usually when paired with other substances.
For the purpose of reducing food intake, 5-HTP should be taken with a meal as it increases satiety from food intake (rather than reducing appetite/hunger).
5-HTP should not be taken with any neurological drug that has been prescribed for antidepressant or other cognitive purposes unless cleared by a medical doctor. This is most important for SSRI usage, wherein the combination with 5-HTP is potentially lethal.
5-HTP Side Effects
Slight Side Effects of 5-HTP
Diarrhea, nausea, or vomiting
Heartburn, gas, or bloating
Stomach discomfort or pain
Decrease in or lack of appetite
Serious Side Effects of 5-HTP
Eosinophilia myalgia syndrome, a condition in which a person may have sudden and severe muscle pain, cramping, trouble breathing, and swelling in the body. Although rare, this condition may take several months to appear.
A blood disorder known as asymptomatic eosinophilia, in which higher than normal levels of special white blood cells called eosinophils are present in the blood. This disorder can generally only be detected through laboratory analysis because patients with this disorder rarely show any symptoms.
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